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KMID : 1039320230230010219
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Journal of Liver Cancer
2023 Volume.23 No. 1 p.219 ~ p.224
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Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma
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Allison Kaye L. Pagarigan
Paulo Giovanni L. Mendoza
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Abstract
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Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatriccases reported in literature. Recounted is a case of a 49-year-old female who presented withacute right upper quadrant abdominal pain, elevated serum alpha fetoprotein and a largeliver mass on imaging. Hepatectomy was performed under clinical suspicion of hepatocellularcarcinoma. Immunomorphologic characteristics of the tumor proved consistent withhepatoblastoma of mixed epithelial and mesenchymal type. Hepatocellular carcinomaremains to be the primary differential diagnosis for adult hepatoblastoma, however, distinguishing between these two neoplasms requires close histomorphologic assessment and immunohistochemical profiling as clinical, radiologic and gross pathologic findings typically overlap. Making this distinction is highly crucial in the timely initiation of surgical and chemotherapeutic interventions for this inherently aggressive and rapidly fatal disease.
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KEYWORD
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hepatoblastoma, Carcinoma, hepatocellular, Pathology, surgical, Immunohistochemistry, Liver cancer
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